The creatingSPARKS festival celebrates creativity at the frontiers of the sciences and the arts. creatingSparks is brought to you by the British Association, Imperial College, The Natural History Museum, the Royal Albert Hall, the Royal College of Art, the Royal College of Music, the Royal Geographical Society, the Science Museum and the Victoria and Albert Museum. For 30,000 years our brains have remained unchanged despite the momentous shift in influences upon them. Now, however, we are faced with the prospect of direct modification to the workings of our brains and hence our minds. Professor Susan Greenfield reviews the possibilities and implications posed by neuroscientific advances for the coming century.