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Whoopi Goldberg stars as Deloris Van Cartier, a Reno lounge singer who accidentally witnesses a brutal murder carried out by her gangster boyfriend Vince (Harvey Keitel). Under the protection of a detective (Bill Nunn) who's trying to bring down Vince's criminal operation, Deloris is placed in protective custody at a San Francisco convent. Masquerading as a nun renamed Sister Mary Clarence, Deloris shakes up the established order of the sisters' lives, particularly enlivening their choral efforts.