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For decades, science fiction has been attempting to escape the constraints of genre, and occasional masterpieces have done just that. But now the practice as a whole is stretching its legs, flexing its muscles and setting up camp in the literary mainstream. Is modern SF's compulsive criss-crossing of genres the kick in the pants contemporary fiction needs? Or is there still further to go? The award-winning literary writer, Toby Litt, one of Granta's 20 Best Young Novelists; John O'Connell, journalist and Time Out reviewer; Muriel Gray and Justina Robson, author of Mappa Mundi and one of our hottest new SF writers talk it over.